Search results for "Hot melt coating"
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Functional characterisation of powders consisting of mixtures of glyceryl behenate and a non-ionic surfactant applied by hot-melt coating: lubricant …
2013
Solid-phase lubricants are routinely used in tablet manufacturing to reduce friction during the densification and ejection phases. However, two main challenges are commonly observed: a) poor blending of the lubricant with the other components; b) increased hydrophobicity of the mix. Hot-melt coating, wherein the substrate is coated with a composite lubricant consisting of glyceryl behenate and a non-ionic surfactant (polyethylene glycol behenate), offers a solution to these challenges. Comparative studies were undertaken using the composite lubricant in a hot-melt coating process and in a ‘standard’ physical blending method. This study shows that the addition of a surfactant to glyceryl beh…
Comparative study of the lubricant performance of Compritol 888 ATO either used by blending or by hot melt coating.
2003
Compritol 888 ATO is used as a lubricant in oral solid dosage formulations. It can also be used as a hot melt coating agent sprayed onto a powder. In this study, we compare the lubricant performance of Compritol 888 ATO either used by classical blending or by hot melt coating onto Lactopress by compression tests. In physical mix, the Compritol concentration does not affect the compressibility. The same compressibility is obtained with lactose coated by 0.5 or 1% of Compritol, but a higher compressibility can be observed with 2 and 3%. Cohesiveness of lactose depends on the process: hot melt coating induces a decrease of tablet tensile strength. In terms of forces transmission during compres…